Modulation of a Shaker potassium A‐channel by protein kinase C activation
- 25 February 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 279 (2) , 256-260
- https://doi.org/10.1016/0014-5793(91)80162-v
Abstract
Brain fast transient K??? channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effects is a small change in the voltage-dependence of activation and inactivation of the channel.Keywords
This publication has 25 references indexed in Scilit:
- Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac libraryFEBS Letters, 1990
- Modulation of vertebrate brain Na+ and K+ channels by subtypes of protein kinase CFEBS Letters, 1990
- Heteromultimeric channels formed by rat brain potassium-channel proteinsNature, 1990
- Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytesNature, 1990
- Substrate‐dependent inhibition of protein kinase C by specific inhibitorsFEBS Letters, 1990
- Isolation of a G Protein that Is Modified by Learning and Reduces Potassium Currents in HermissendaScience, 1990
- Blockade of ion channel expression in xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAsNeuron, 1988
- Forskolin and Phorbol Esters Reduce the Same Potassium Conductance of Mouse Neurons in CultureScience, 1987
- Adenosine-induced slow ionic currents in the Xenopus oocyteNature, 1982
- Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pHPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975