ROLE OF MOUSE IGG AND IGE HOMOCYTOTROPIC ANTIBODIES IN PASSIVE CUTANEOUS ANAPHYLAXIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 32  (4) , 507-511
Abstract
The role of mouse homocytotropic antibodies in the passive cutaneous anaphylaxis reaction was investigated. One class of antibody was heat stable, detected at 2 h but not at 48 h after passive transfer, and belonged to a subclass of mouse Ig[immunoglobulin]G. The other was heat labile, detected at 2 h and 48 h after passive transfer, and belonged to the IgE class of mouse Ig. In the presence of IgG, IgE homocytotropic antibody was not detected early after passive transfer. This was probably due to a masking of IgE by IgG antibodies rather than a competition for mast cell surface receptors, since inhibition studies with rat IgE myeloma protein suggested that mouse IgE and IgG/1 may have different receptor sites on mast cell surfaces.