Immunologic responses to a murine mammary adenocarcinoma. II. Monocyte effector activation by humoral factors
- 15 May 1977
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 19 (5) , 717-724
- https://doi.org/10.1002/ijc.2910190518
Abstract
Sera from DBA/2 mice bearing a syngeneic T1699 mammary adenocarcinoma not only induced specific antibody‐dependent cellular cytotoxicity (ADCC) mediated by monocytes (and/or macrophages) but also armed (activated) such effector cells into specific killer cells in vitro. Removal of specific anti‐tumor antibody (IgG2a subclass) by absorption with T1699 cells abolished the ADCC activity at the level of target cell coating but did not alter the level of effector‐arming activity. Fractionation on Sephadex G‐20 indicated more than one factor capable of inducing specific monocyte‐mediated lysis of target cells in vitro, including immune complexes, free IgG2a 7S antibody (ADCC), and another factor(s) with a molecular weight very close to that of 7S immunoglobulins.This publication has 16 references indexed in Scilit:
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