Identification of and Human Serum Reactogenicity to Neutralizing Epitopes within the Central Unglycosylated Region of the Respiratory Syncytial Virus Attachment Protein
- 1 April 2010
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 17 (4) , 695-697
- https://doi.org/10.1128/cvi.00432-09
Abstract
We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In ∼40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of ≥4-fold increases in IgG response between acute- and convalescent-phase sera.Keywords
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