Internal Dose from Carbon-14 Labelled Compounds. The Metabolism of Carbon-14 Labelled Potassium Cyanide in the Rat

Publisher Website
Google Scholar
Abstract
The metabolism of 14C-labeled potassium cyanide in the rat after i.v. injection, pulmonary and gastric intubation and skin absorption was studied. The pattern of excretion and tissue levels of the 14C activity was similar for the i.v. and pulmonary routes, but some differences in tissue distribution were apparent after skin absorption. After i.v. injection, 45% of administered activity was excreted in urine within 24 h and 74% by 60 days after administration. The corresponding values after 60 days were 8% for breath and 15% for feces. The time integrals of concentration of activity in the body were determined from cumulative excretion data and the internal dose from 14C-labeled potassium cyanide calculated. The committed human dose equivalentto whole body from an intake of 1 .mu.Ci was as 1.6 .times. 10-4 rems.