STUDIES IN GLYCINE-2-C14 METABOLISM IN MAN. I. THE PULMONARY EXCRETION OF C14O21

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Abstract
100 uc of glycine 2-C14 was administered to 4 patients with either polycythemia or leukemia. An avg. of 87% of the injected C14 dose was excreted by the lungs as C14O2, in 3 rate processes, with half times 2.5 in 33 hrs.; 16 in 40 hrs., and 163 in 336 hrs. Within the first 10 days approx. 5% was excreted in the urine and a negligible amt. in the feces. On autopsy 106 days after admn. 1 subject showed retention of approx. 10% within the body; this suggests that there is a 4th component of breath elimination, with specific activity too weak to measure with present routine methods and a calculated half-time of at least 90 days. In the dosage level given, C14 is without hazard to the patient from the standpoints of retention within the body and radiation dose to the tissues.