Treatment of 'cimetidine-resistant' chronic duodenal ulcers with ranitidine or cimetidine: a randomised multicentre study.

Publisher Website
Google Scholar
Abstract
Forty patients with endoscopically proven persistent duodenal ulcer who were treated for 6 wk with cimetidine (1 g/day) were randomly allocated to receive a further 6 wk treatment with cimetidine (1 g/day) or rantidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of 21 given ranitidine (62%); 2 patients on cimetidine and 2 on ranitidine dropped out. In the unhealed ulcer group the ulcer size was reduced in most patients. There was no change in basal acid output, peak acid output, plasma gastrin and pepsinogen I levels after either treatment. Clinical data, gastric function tests, and endoscopic features did not predict ulcer healing. Both treatments were effective in the relief of pain: 72% of patients with unhealed ulcers were asymptomatic at the end of the trial.