Five-Year Follow-up of Pulmonary Function and Peak Oxygen Uptake in 16-Year-Old Boys with Cystic Fibrosis, with Special Regard to the Influence of Regular Physical Exercise

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Abstract
Eight Norwegian boys with cystic fibrosis (CF) 16 years of age were included in a 5-year follow-up study. They underwent pulmonary function and bicycle exercise tests 2-16 times each. The individual''s habitudinal level of physical exercise was registered by interviews and training diaries to study whether it could be correlated to the developments in lung function, peak oxygen uptake (peak .ovrhdot.VO2), and Shwachman score. The boys were characterized by a large interindividual variation in both lung function, peak .ovrhdot.VO2, and Shwachman score at the first test in the study. Four boys trained regularly 3-9 h weekly, while the four others had no regular exercise. Two of the latter, who also had the lowest Shwachman scores, died during the study. The other two in the nontraining group deteriorated significantly in clinical scores, lung function variables, and peak .ovrhdot.VO2 during the study period of 5 years. The four boys in the training group improved in lung function and peak .ovrhdot.VO2 in accordance with or even better than expected in healthy adolescent boys during the same growth period. Even though the material is small, and several factors might influence the results, the study indicates that regular physical exercise has beneficial long-term effects on lung function, physical fitness, and Shwachman score in adolescent CF boys.