Effects of salicylate on RNA polymerase activity and on the incorporation of orotic acid and thymidine into the nucleic acids of rat foetuses in vitro

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Abstract
Salicylate (10 mM) significantly inhibited the activity of RNA polymerase and the incorporation of radioactivity from orotic acid-5-3H and thymidine-6-3H into whole 13 day and 16 day rat foetuses. The polymerase activity and the incorporation of the labelled orotate were significantly inhibited by 2 mM salicylate in the 16 day foetus only. The inhibitory action of salicylate on RNA biosynthesis may be related to its effects in causing an increased incidence of foetal death and congenital malformation in pregnant rodents.