RATE OF DISAPPEARANCE OF GROWTH HORMONE FROM THE PLASMA OF RATS AFTER A SINGLE INTRAVENOUS INJECTION

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Abstract
The fall in concentration of the hormone was determined by injecting lyophilized samples of the plasma into hypophysectomized rats, and using the tibial epiphyseal cartilage width assay. The concentration of the injected growth hormone fell exponentially as a function of time with a biological half life of 40 minutes. By extrapolation to zero time, it was estimated that only about 1B of the injected dose could be found in the plasma immediately after injection.