Bile ducts as a source of pancreatic β cells
- 17 August 2004
- Vol. 26 (9) , 932-937
- https://doi.org/10.1002/bies.20090
Abstract
In recent years, there have been a number of well‐documented examples demonstrating that one cell type can be converted to another. Two such examples are the appearance of ectopic pancreas in the liver and formation of hepatic tissue in the pancreas. The conversion of liver to pancreas raises the intriguing possibility of generating insulin‐producing β cells for therapeutic transplantation into diabetics. There is now a striking addition to the growing list of pancreatic conversions: the formation of pancreatic tissue in the developing biliary system.1 BioEssays 26:932–937, 2004.Keywords
This publication has 34 references indexed in Scilit:
- Conversion of biliary system to pancreatic tissue in Hes1-deficient miceNature Genetics, 2003
- Functional, Persistent, and Extended Liver to Pancreas TransdifferentiationJournal of Biological Chemistry, 2003
- Altered Notch Ligand Expression in Human Liver DiseaseThe American Journal of Pathology, 2002
- Transdifferentiation and metaplasia — switching cell typesCurrent Opinion in Genetics & Development, 2001
- Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endodermGenes & Development, 2001
- Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genesGenes & Development, 2001
- Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1Nature Genetics, 1997
- Insulin-promoter-factor 1 is required for pancreas development in miceNature, 1994
- Development of the adult endocrine pancreas during metamorphosis in the sea lamprey, Petromyzon marinus L. II. Electron microscopy and immunocytochemistryThe Anatomical Record, 1993
- Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 casesThe Journal of Pediatrics, 1987