Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems

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Abstract
Highly active antiretroviral therapy (HAART) delays disease progression and death.1–4 However, the treatments incompletely control HIV replication,5–7 only partially restore immune function,8,9 have significant short- and long-term toxicities,10–14 and eventually fail in many patients with consequent development of HIV drug resistance.6 Thus, there is increasing need for information to guide HIV-infected patients and their providers in making decisions regarding optimal use of antiretroviral therapies. Although clinical trials provide valuable information about efficacy and side effects of antiretroviral treatment, they have limited size, duration and power to detect effects on clinical outcomes, focusing instead on surrogate endpoints such as virologic failure, treatment discontinuation or composite outcome measures.15