Update on toll-like receptor-directed therapies for human disease
- 1 November 2007
- journal article
- review article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 66, iii77-iii80
- https://doi.org/10.1136/ard.2007.078998
Abstract
Innate responses to microbes are mediated in large part by toll-like receptors (TLRs), which recognise a diverse range of molecules produced by viruses, bacteria and fungi. Great effort has been directed towards translating this knowledge into the development of new therapies for a wide spectrum of diseases, including infectious, malignant, autoimmune and allergic diseases. This review will provide a brief update on completed, ongoing and planned clinical trials of TLR ligand-based therapies for the treatment of diseases in humans.Keywords
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