New Surface Antigen in Cells Transformed by Simian Papovavirus SV40.

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Abstract
Summary Hamster cells transformed by papovavirus SV40 in vitro and in vivo possess new surface antigens that can be detected by the indirect immunofluorescent technic. Antibody against the surface antigens of the SV40-transformed cells fail to react with normal cells from various species including the hamster, with the “spontaneously” oncogenic hamster BHK21 cells, or with hamster cells transformed by adenovirus type 12. Inoculation of hamsters with cells not transformed by SV40 did not elicit synthesis of an antibody capable of reacting with the surface antigens of the cells transformed by the papovavirus.