Experimental herpes simplex virus carditis in mice

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Abstract
Herpes simplex virus [HSV] types 1 and 2 induced acute and chronic cardiac damage in suckling and weanling mice after intranasal inoculation. Signs of virus replication were detected by light, immunofluorescent and EM techniques. Virtually all cardiac tissues appeared susceptible to HSV, the myocardium was most regulary affected. The viral lesions were discrete during the acute phase of infection, but cardiac damage was more extensive in some chronically infected mice. Morphologically, these lesions resembled the acute ones or were associated with inflammatory granulomatous and sclerotic changes.