THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS
Open Access
- 1 February 1964
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 119 (2) , 343-356
- https://doi.org/10.1084/jem.119.2.343
Abstract
The pathogenesis of herpes simplex virus encephalitis and myelitis was studied in suckling mice using routine titration procedures and fluorescent antibody staining for the identification of infected cells. After intracerebral inoculation virus was shown to disperse rapidly in the cerebrospinal fluid (CSF), multiply in meninges and ependyma, and then invade the underlying parenchyma infecting both neurons and glia.Keywords
This publication has 22 references indexed in Scilit:
- Central nervous system syndromes of “viral” etiology: A study of 713 casesThe American Journal of Medicine, 1960
- Studies on canine distemper infection by means of fluorescein-labeled antibodyVirology, 1957
- Cellular localization of herpes simplex virus by means of fluorescent antibodyVirology, 1956
- VISUALIZATION OF EGYPT 101 VIRUS IN THE MOUSE'S BRAIN AND IN CULTURED HUMAN CARCINOMA CELLS BY MEANS OF FLUORESCENT ANTIBODYThe Journal of Experimental Medicine, 1955
- Emerging Concept of Poliomyelitis InfectionScience, 1955
- Intracerebral Inoculation of Mice: Fate of the InoculumNature, 1950
- STUDIES ON HERPETIC INFECTION IN MICEThe Journal of Experimental Medicine, 1943
- EXPERIMENTAL ENCEPHALITISThe Journal of Experimental Medicine, 1940
- STUDIES ON PSEUDORABIES (INFECTIOUS BULBAR PARALYSIS, MAD ITCH)The Journal of Experimental Medicine, 1933
- CONTRIBUTIONS TO THE PATHOLOGY OF EXPERIMENTAL VIRUS ENCEPHALITISThe Journal of Experimental Medicine, 1925