Abstract
In 25 cats and 13 monkeys, different regions of the limbic system of the brain were electrically stimulated in unanesthetized condition through implanted multilead electrodes, and their blood pressure and respiration recorded. Stimulation of frontal lobe structures generally produced a rise in blood pressure (BP) and acceleration of respiration in majority of them. Temporal lobe stimulation generally produced a fall in BP and inhibition of respiration in majority. Temporal polar stimulation produced a rise of BP in monkeys and a fall in cats. Changes in the heart rate produced had no relationship to the rise or fall of BP and both increase and decrease were elicited.