Fatal complications after myelography with meglumine diatrizoate
- 1 January 1990
- journal article
- case report
- Published by Springer Nature in Neuroradiology
- Vol. 32 (1) , 70-73
- https://doi.org/10.1007/bf00593948
Abstract
A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.Keywords
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