First evidence of spontaneous deamidation of glutamine residue via cyclic imide to α- and γ-glutamic residue under physiological conditions
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1667-1668
- https://doi.org/10.1039/c39910001667
Abstract
At 37 °C and pH 7.4 the spontaneous deamidation of Gln-peptide proceeds prevalently via a glutarimide intermediate and gives a mixture of α-Glu- and γ-Glu-peptide.Keywords
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