Effects of Low Doses of Cyproterone Acetate on Sperm Morphology and some other Parameters of Reproduction in Normal Men

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Abstract
Cyproterone acetate was given to 3 healthy men in a dosage of 10 mg/day for 8-14 wk. The effects on sperm count, morphology, motility and vitality was followed weekly and compared with the effects of 25 mg daily in another case. Sperm morphology included the study of live spermatozoa separately. The effects on serum levels of FSH, LH [lutropin], testosterone and estrogens was also studied. With respect to sperm count and morphology a dose-effect relationship is indicated. Abnormalities within tails and midpieces of live spermatozoa appear early and may predict sterility before azoospermia develops. FSH and estrogen were comparatively more depressed than LH and testosterone. Cyproterone acetate may have an androgenic (or gestagenic) effect on the hypophyseo-hypothalamic level in addition to an antiandrogenic effect on gonads and their accessory organs.