Inhibition of Low Density Lipoprotein Oxidation by Myrigalone B, a Naturally Occurring Flavonoid
- 1 March 1996
- journal article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 78 (3) , 143-146
- https://doi.org/10.1111/j.1600-0773.1996.tb00195.x
Abstract
The influence of myrigalone B, a flavonoid from the fruit exudate of Myrica gale L. on Cu(2+)-induced oxidation of low density lipoprotein from cholesterol fed rabbits was investigated. Myrigalone B was an effective antioxidant, as shown by its ability to dose-dependently prolong the lag time for the formation of conjugated dienes. A 100% increase in lag time corresponds to a myrigalone B concentration of 1.4 +/- 1.1 microM. For alpha-tocopherol, used as a reference, this effect corresponds to a concentration of 1.9 +/- 1.2 microM. Myrigalone B also dose-dependently reduced the maximum rate of formation of conjugated dienes, 1.4 microM causing a 15 +/- 5% reduction, but it had no influence on the maximal amount of conjugated dienes formed.Keywords
This publication has 19 references indexed in Scilit:
- C-Methylated Dihydrochalcones fromMyrica galeL: Effects as Antioxidants and as Scavengers of 1,1-Diphenyl-2-PicrylhydrazylBasic & Clinical Pharmacology & Toxicology, 1996
- Antioxidant Activity of Fruit Exudate andC-Methylated Dihydrochalcones fromMyrica galePlanta Medica, 1995
- Contribution of vitamin A to the oxidation resistance of human low density lipoproteinsFree Radical Biology & Medicine, 1995
- Mechanistic and genetic aspects of susceptibility of LDL to oxidationCurrent Opinion in Lipidology, 1993
- Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wineThe Lancet, 1993
- The inhibition of the oxidation of low density lipoprotein by (+)-Catechin, a naturally occurring flavonoidBiochemical Pharmacology, 1992
- Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines☆Free Radical Biology & Medicine, 1992
- α-tocopherol consumption during low-density-lipoprotein oxidationBiochemical Journal, 1990
- The Role of Vitamin E and Carotenoids in Preventing Oxidation of Low Density LipoproteinsaAnnals of the New York Academy of Sciences, 1989
- Continuous Monitoring ofin VztroOxidation of Human Low Density LipoproteinFree Radical Research Communications, 1989