INEFFECTIVENESS OF ADRENAL CORTEX PREPARATIONS IN THE TREATMENT OF EXPERIMENTAL SHOCK IN NONADRENALECTOMIZED DOGS

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Abstract
The therapeutic value of adrenal cortical extract and of the synthetic adrenal steroid desoxycorticosterone acetate has been tested in a series of non-adrenalectomized dogs, shocked by 3 different procedures: 1) release of tight tourniquets applied to both hind legs for a 5 hr. constriction period; 2) trauma to muscle masses of both hind legs; and 3) venous occlusion of 1 hind leg. The major factor leading to shock in the 1st and 3rd procedures is an extensive local fluid loss into the injured areas. Both local fluid loss and nervous factors contribute to the shock following muscle trauma. DCA proved ineffective upon survival in all 3 types of shock. Likewise, cortical extract in large amts. did not prevent shock, hasten the rehabilitation of the vasculature in the injured areas, or increase the efficacy of a plasma transfusion. An explanation is offered, based upon probable differences in etiology, of circulatory failure in the adrenalectomized animal and shock in the non-adrenalectomized animal, for this failure of cortical hormones to increase the resistance of the intact dog to shock inducing procedures.

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