rheumatoid factors in primary and reactive macroglobulinaemia.

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Abstract
Sera from African patients with various kinds of reactive macroglobulinaemia and from European patients with IgM-paraproteinaemia were investigated in the latex-fixation test and the Waaler-Rose test, and compared with diseased control groups. Trypanosomiasis sera gave a significantly increased number of positive reactions, but only in the Waaler-Rose test. For chronic African splenomegaly and other forms of reactive macroglobulinaemia, an increase in positive reactions was observed but this was of lesser degree and not restricted to one type of test. Sera from cases of Waldenstrom''s macroglobulinaemia did not give a significantly increased number of reactions in the latex-fixation test, when compared with diseased controls. The same is probably true for the Waaler-Rose test. Conditions accompanied by an increased level of reactive IgM-globulin in the serum give more false positive reactions, but that the nature of these conditions determines the level of significance as well as the substrate specificity of the rheumatoid serum factors.

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