A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens.
Open Access
- 1 April 1997
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 105 (suppl 3) , 665-668
- https://doi.org/10.1289/ehp.97105s3665
Abstract
Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.Keywords
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