Effect of 13‐NLE‐motilin on gastric secretion, serum gastrin level and mucosal blood flow in dogs.

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Abstract
In dogs with gastric fistulas and vagally innervated fundic and antral pouches, 13-norleucine-motilin (13-nle-motilin), a synthetic analogue of motilin, infused i.v. in graded doses produced a dose-dependent increase in gastric acid and pepsin outputs. The motilin-induced stimulation of gastric secretion occurred independently of antral pH and was not accompanied by any alteration in the serum gastrin level, suggesting that motilin did not affect the release of gastrin. When infused i.v. in a constant dose against a constant background stimulation with pentagastrin or histamine, 13-nle-motilin inhibited both acid and pepsin secretion from the main stomach and fundic pouch. The inhibitory effect of 13-nle-motilin was always associated with a marked reduction in mucosal blood flow but without any change in the ratio of aminopyrine concentration in the gastric juice and blood plasma, indicating that this peptide primarily affected gastric secretion but did not limit the gastric mucosal microcirculation.