INCREASED MITOTIC ACTIVITY IN THE GLANDULAR STOMACH OF THE RAT FOLLOWING HYPOPHYSECTOMY

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Abstract
Eight Sprague-Dawley rats were hypophysectomized at 40 gm.; one was sham-operated. Sixteen days afterwards, 4 of the hypophysectomized animals were injected with STH (Somar, Armour), 20 [mu]g. daily for 5 days. At this time, these animals and also 3 normal controls were labeled with 50 [mu]c. thymidine H3 and sacrificed 24 hrs. later. Integrated autoradiographs coated with liquid NTB3 emulsion were exposed for 3 months. The number of H3 positive cells in the glandular stomach was twice as large in the hypophysectomized group as compared to the controls and sham-operated. The growth hormone treated animals were comparable to the nontreated. The H3 autoradiographic record was largely localized in all cases to the isthmus of the gastric glands.