Ethnicity and adverse drug reactions

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Abstract
Optimising dose Indeed, there is a growing body of evidence from detailed pharmacogenetic studies that various populations may differ significantly in the distribution of allelic variants of important enzymes that determine drug disposition or variants of drug receptors.7 8 Such information about individual genotype could lead to dose optimisation, thus avoiding concentration dependent toxicity caused by drugs such as oral anticoagulants or antiarrhythmic drugs.8 9 Finding genetic markers for severe adverse drug reactions would help to identify patients at high risk before the start of specific treatment. Such findings would also serve as valuable support in establishing causality in complex cases where patients have taken more than one suspect drug.