High 1,25‐Dihydroxyvitamin D and Low 25‐Hydroxyvitamin D Concentrations in Plasma in Patients Receiving Antiepileptic Drugs

Publisher Website
Google Scholar
Abstract
Plasma 25‐hydroxyvitamin D (25‐OH D), 1,25‐dihydroxy vitamin D (1,25‐(OH)2 D) and parathyroid hormone (PTH) concentrations were determined in 30 outpatients receiving various antiepileptic drugs (AED). None of the patients exhibited high plasma PTH levels. The plasma 1,25‐(OH) 2 D levels were normal or high, a'though in a third of the patients the 25‐OH D levels were reduced. There was a corre'ation between the 25‐OH D and serum calcium levels. These findings suggest that the low plasma concentrations of 25‐OH D, not 1,25‐(OH)2 D, might play an important part in the occurrence of AED‐induced disturbances of bone metabolism.