Ultrastructure of the thymus in chicks inoculated with chicken anaemia agent (msb1-tk5803 strain)

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Abstract
Mild depletion of thymocytes, with swelling of thymic lymphoblasts was observed 1 week post inoculation (pi). The affected cells had irregular nuclei and frequently contained intranuclear inclusion bodies consisting of fine granular or homogenous materials. Electron‐opaque regions, microtubules and autophagosomes were also present in the cytoplasm of affected cells. Aggregation of virus‐like particles of 14 to 18 nm in diameter was rarely observed in the degenerative cells. The reticular cells with elaborate cytoplasmic meshwork were prominent 2 weeks pi. Repopulation of thymic lymphoblasts was marked in the cortex 3 weeks pi. The fine structure of the thymic cortex is also described.

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