Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment
- 1 November 1982
- journal article
- Published by Springer Nature in Nature
- Vol. 300 (5887) , 19-23
- https://doi.org/10.1038/300019a0
Abstract
The pathogenesis of infection of mice by the mammalian reoviruses involves several discrete steps. Each of the three viral outer capsid proteins has a highly distinct and specialized role: one protein (sigma 1) binds to cell surface receptors; a second protein (mu 1C) determines the capacity for viral growth at mucosal surfaces; and the third protein (sigma 3) is responsible for inhibiting cell macromolecular synthesis. A detailed picture of the molecular basis of reovirus virulence and attention is now emerging.Keywords
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