Sulfamethazine: In Vitro Action on Enteric Pathogens as Compared with Sulfadiazine and Sulfamerazine

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Abstract
Sulfamethazine in vitro is by far a more effective bactericidal and bacteriostatic agent than the other sulfonamides examined against Eberthella typhosa, Escherichia coli, and the Salmonella vars. A similar conclusion may be drawn in its use against Shigella sonnei and the Hiss dysentery strain. The drug is effective in the test tube on the typhoid-colon group in concs. which would suggest that clinical applications should be attempted, especially since all other sulfonamides offer no convincing evidence of their ability to combat cases of typhoid fever or of its chronic carrier state (Long, 1941; Cutting and Robson, 1942; Kirby and Rantz, 1942) and of the Salmonella infections (Born-stein and Strauss, 1941; Bornstein, 1943).