EFFECTS OF ANTI-ANTIBODY ON IMMUNE HAEMOLYSIS

  • 1 January 1964
    • journal article
    • research article
    • Vol. 7  (3) , 217-+
Abstract
Guinea-pig-produced antibody against whole rabbit serum inhibits complementary lysis (guinea-pig complement) of sheep cells sensitized with rabbit-produced haemolysin. The inhibitory agent (guinea-pig antibody) is termed "anti-sensitizer". Each of the following factors, when varied alone, decreases the degree of inhibition of lysis at constant anti-sensitizer concentration: increase in sensitizer concentration, increase in complement and increase in the length of incubation. The relative proportions of complement and anti-sensitizer can be absorbed on and eluted from sensitized cells. The inhibition of lysis is not due to destruction of complement.