Squamometry: an evaluation method for a barrier protectant (tannic acid)
- 1 April 1999
- journal article
- Published by Wiley in Contact Dermatitis
- Vol. 40 (4) , 189-191
- https://doi.org/10.1111/j.1600-0536.1999.tb06031.x
Abstract
Squamometry for evaluating skin barrier substances is described. Forearms of 8 volunteers were dosed with 0, 0.25, 0.5, and 1% sodium lauryl sulfate (SLS) in distilled water (semi‐open method) for 24 h, to skin pretreated with distilled water and 5% tannic acid, a model barrier protectant. Squamometric evaluation indicated the skin damage increased with SLS concentration in a dose‐dependent manner, and that tannic acid reduced the damage (p<0.01). The results suggest that squamometry may be a useful method for determining efficacy of skin barrier substances.Keywords
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