N-Nitroso-N-methylurea elicits mammary cancer in resistant and sensitive rat strains.
- 1 February 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (2) , 1185-1188
- https://doi.org/10.1073/pnas.78.2.1185
Abstract
A single i.v. injection of the water-soluble mammary carcinogen N-nitroso-N-methylurea (NMU; 35 mg/kg of body wt) elicited cancer of the breast in young female rats of 2 strains in the following incidence: Long-Evans strain, 4%; Sprague-Dawley strain, 79%. In sisters of these rats, a set of 5 i.v. injections of NMU (35 mg/kg at biweekly intervals) evoked mammary carcinoma as follows: Long-Evans strain, 76%; Sprague-Dawley strain, 100%. In its effectiveness in evoking mammary cancer in Sprague-Dawley rats, the lipid-soluble mammary carcinogen 7,8,12-trimethylbenz[a]anthracene exceeded NMU in rapidity of development of cancer and in tumor yield.This publication has 9 references indexed in Scilit:
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