Absorption of soluble and isophane semi-synthetic human and porcine insulin in insulin-dependent diabetic subjects

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Abstract
A double-blind cross-over study of the sc absorption of radiolabelled semi-synthetic human (SHI) and purified porcine (PPI) insulin was made. Absorption of both isophane (n = 10) and soluble insulin (n = 8) was studied. There was no significant difference between the disappearance from the injection site, the plasma free insulin concentrations, or blood glucose levels after sc injection of the isophane preparations. A faster disappearance of the soluble SHI (as judged from T/50 and AUC) was found (both P-values < 0.01). However, no difference was observed between the plasma insulin concentrations at any time point (P < 0.05). Blood glucose levels showed no statistical differences between the two soluble preparations. The data indicate minor differences between the pharmaco-kinetics of SHI and PPI, but these seem of no clinical importance.