Liquid-Phase Combinatorial Synthesis of Alicyclicβ-Lactams via Ugi Four-Component Reaction
- 1 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (11) , 1967-1969
- https://doi.org/10.1021/ol025986r
Abstract
Alicyclic β-lactams were successfully synthesized via a parallel liquid-phase Ugi four-center three-component reaction (U-4C-3CR), starting from alicyclic β-amino acids such as cis-2-aminocyclohexanecarboxylic acid, cis-2-aminocyclopentanecarboxylic acid, 2,3-diexo-3-aminobicyclo[2.2.1]heptane-2-carboxylic acid and some of their partially unsaturated analogues. A six-membered mixture-based combinatorial library of β-lactams was also generated.Keywords
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