Transcriptional repression mediated by the serum response factor
- 2 January 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 357 (1) , 45-49
- https://doi.org/10.1016/0014-5793(94)01321-q
Abstract
The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF functionKeywords
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