PATHOGENESIS OF DUODENAL-ULCER - GASTRIC HYPER-ACIDITY CAUSED BY PROPIONITRILE AND CYSTEAMINE IN RATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (2) , 311-323
Abstract
Cysteamine and propionitrile, experimental duodenal ulcerogens, stimulated gastric acid secretion in the rat. Gastric acid secretion was measured by 2 separate methods, the conventional pylorus ligation technique and a non-invasive technique based on the pH dependent liberation of azure A from azuresin in the stomach with subsequent excretion of the liberated dye in the urine. Volume, acid concentration and acid content of gastric fluids aspirated immediately before the pylorus ligation were markedly increased 1, 4 and 7 h after a single dose of either cysteamine or propionitrile. Acid concentration and acid output of gastric contents collected 30 min after pylorus ligation were significantly elevated 1.5 h after propionitrile and 4.5 h after cysteamine. Significant increases in gastric acid secretion after these chemicals were measured by the non-invasive technique which demonstrated a 4- to 6-fold increase in 24 h urinary azure A output in rats injected with either propionitrile or cysteamine. Enhanced gastric acid output may play an important role in the pathogenesis of duodenal ulcer produced by propionitrile and cysteamine.