PHOSPHORUS METABOLISM OF THE ADRENAL GLAND: EFFECT OF HYPOPHYSECTOMY AND ADMINISTRATION OF ACTH ON THE INCORPORATION OF RADIOACTIVE PHOSPHATE INTO PHOSPHOLIPID1

Publisher Website
Google Scholar
Abstract
GEMZELL and Samuels (1950) investigated the incorporation of inorganic phosphate labeled with P32 into the inorganic phosphate fraction of a number of organs of normal and hypophysectomized rats. They found that hypophysectomy caused a decrease in the specific activity of the inorganic phosphate of the adrenal gland relative to that of the inorganic phosphate of the plasma. A normal rate of incorporation of P32 into the inorganic phosphate of the adrenal was largely restored by a single injection of ACTH. Reiss and Halkerston (1950) made similar observations for the total acid-soluble phosphorus fraction of the adrenal gland. These findings were, in the main, confirmed by Riedel, Logan, DeLuca and Rossiter (1954). Evidence was presented by Riedel and Rossiter (1954) for the suggestion of Gemzell and Samuels (1950) that in the adrenal gland of hypophysectomized rats there is a defect in the passage of inorganic P32 from the extracellular to the intracellular portion of the gland.