SUBSTANCE-P, A NEUROPEPTIDE, INHIBITS MEASLES-VIRUS REPLICATION IN CELL-CULTURE
- 1 September 1986
- journal article
- research article
- Vol. 30 (5) , 432-435
Abstract
Substance P, a neuropeptide of the tachykinin group, inhibits measles virus replication in cell culture and partially blocks viral fusion activity assayed in the hemolysis system. The ID50 for the inhibition of measles virus single-cycle replication is 0.6 .mu.mol/l, and the effect is fully reversible. The antiviral activity of substance P corresponds to that of previously described synthetic tri-to heptapeptides. Tachykinins and these oligopeptides share a short homology with the N-terminus of paramyxovirus fusion proteins.This publication has 10 references indexed in Scilit:
- Measles encephalomyelitis: Lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelinationAnnals of Neurology, 1984
- ANTIVIRAL ACTIVITY OF NORAKIN-R (TRIPERIDEN) AND RELATED ANTICHOLINERGIC ANTIPARKINSONISM DRUGS1984
- Oligopeptides that specifically inhibit membrane fusion by paramyxoviruses: Studies on the site of actionVirology, 1983
- Inhibition of measles virus budding by phenothiazinesVirology, 1983
- Rapid degradation of [3H]‐substance P in guinea‐pig ileum and rat vas deferens in vitroBritish Journal of Pharmacology, 1983
- Reversible repression and activation of measles virus infection in neural cells.Proceedings of the National Academy of Sciences, 1982
- Inhibition of measles virus replication by cyclic AMPVirology, 1980
- Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the Fl or HA2 viral polypeptidesVirology, 1980
- Substance P: In vitro inactivation by rat brain fractions and human plasmaBiochemical Pharmacology, 1979
- Successive cleavage of N-terminal Arg1-Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidaseBiochimica et Biophysica Acta (BBA) - Enzymology, 1978