Two new restriction endonucleases from Proteus vulgaris

Abstract
Two novel sequence-specific endonucleases have been isolated from Proteus vulqaris, ATCC 13315. PvuI recognizes the sequence: 5′ C G A T↓C G 3′ 3′ G C↑T A G C 5′ and PvuII recognizes the sequence: 5′ C A G↓C T G 3′ 3′ G T C↑G A C 5′ and cleave as indicated by the arrow (+). PvuI is an isoschizomer of XorII, RshI, and XniI. No enzyme with the specificity of PvuII has been described previously.