Influence of High Plasma Concentrations of Free Fatty Acids on Heart Rhythm in Healthy Fasting Men
- 12 January 1979
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 205 (1-6) , 299-301
- https://doi.org/10.1111/j.0954-6820.1979.tb06051.x
Abstract
Ten healthy male students in regular sinus rhythm fasted for 66 h. Their overnight fasting plasma concentration of free fatty acids (FFA) was 455 .+-. 104 .mu.mol/l (mean .+-. SEM [standard error of the mean], n = 7), the reference value of the laboratory, measured in another normal population of young men, being 344 .+-. 28 .mu.mol/l (n = 10). After 42 and 66 h of fasting, the plasma concentration of FFA rose to 1198 .+-. 181 (P < 0.01, n = 10) and 1471 .+-. 89 .mu.mol/l (P < 0.001, n = 10), respectively. During the last 24 h of fasting, the heart rhythm was monitored continuously by means of a Holter recorder and computer. No arrhythmias were observed; elevated plasma concentrations of FFA, exceeding those reported in patients with acute myocardial infarction, are well-tolerated by the healthy human myocardium.Keywords
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