Biotransformation of Perchloroethene: Dose-Dependent Excretion of Trichloroacetic Acid, Dichloroacetic Acid, andN-acetyl-S-(trichlorovinyl)-l-Cysteine in Rats and Humans after Inhalation
- 30 November 1998
- journal article
- research article
- Published by Elsevier in Toxicology and Applied Pharmacology
- Vol. 153 (1) , 20-27
- https://doi.org/10.1006/taap.1998.8548
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- The Role of Cytochrome P450 2E1 in the Species-Dependent Biotransformation of 1,2-Dichloro-1,1,2-Trifluoroethane in Rats and MiceToxicology and Applied Pharmacology, 1995
- Metabolism of Tetrachloroethene in Rats: Identification of N.epsilon.-(Dichloroacetyl)-L-lysine and N.epsilon.-(Trichloroacetyl)-L-lysine as Protein AdductsChemical Research in Toxicology, 1994
- Quantitation of the tetrachloroethylene metaboliteN-acetyl-S-(trichlorovinyl)cysteine in rat urinevia negative ion chemical ionization gas chromatography/tandem mass spectrometryJournal of Mass Spectrometry, 1994
- Thioketene formation from .alpha.-haloalkenyl 2-nitrophenyl disulfides: models for biological reactive intermediates of cytotoxic S-conjugatesJournal of the American Chemical Society, 1991
- Biosynthesis, bioactivation, and mutagenicity of S-conjugatesToxicology Letters, 1990
- Bioactivation of Nephrotoxic Haloalkenes by Glutathione Conjugation: Formation of Toxic and Mutagenic Intermediates by Cysteine Conjugate β-LyaseDrug Metabolism Reviews, 1989
- Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate .beta.-lyaseChemical Research in Toxicology, 1988
- Bacterial β-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadieneChemico-Biological Interactions, 1986
- Identification of S‐1,2,2‐trichlorovinyl‐N‐acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicityJournal of Biochemical Toxicology, 1986
- Metabolism of trichloroethylene in manArchives of Toxicology, 1972