A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo

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Abstract
A heat-labile lipid inhibitor of blood coagulation was extracted from brain tissue, differing in potency, solubility, chemical nature and physiologic action from other known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithromboplas- tin "in vitro" is still less than that of heparin, it has "in vivo" a more lasting effect when injected intraven. than a soln. of heparin of equivalent anticoagulant potency.

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