LUNG MUCOCILIARY CLEARANCE AFTER ANESTHESIA WITH SPONTANEOUS AND CONTROLLED VENTILATION

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Abstract
Anesthesia and controlled ventilation for 2 h delayed mucociliary clearance from the lung. To elucidate the contribution of controlled ventilation, mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in 6 dogs. After an induction dose of 25 mg of thiopental/kg of body weight, tantalum insufflation and immediate recovery from anesthesia, 7 .+-. 7% of the tantalum remained in peripheral airways at 6 h. This was not significantly different from the 16 .+-. 7% remaining at 6 h when the dogs breathed humidified air spontaneously through an endotracheal tube during 2 h of anesthesia with thiopental (total 40 mg/kg of body weight). When ventilation was controlled during 2 h of anesthesia with 40 mg of thiopental/kg, with a tidal volume of 10 ml/kg or 30 ml/kg, and with a partially deflated endotracheal tube cuff, 43 .+-. 11% and 48 .+-. 9% of the tantalum, respectively, remained in peripheral airways at 6 h. Peripheral lung mucociliary clearance is delayed by mechanical ventilation through an endotracheal tube, even with an inspiratory air leak, independent of the tidal volume chosen.

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