Leukopenia: Idiopathic or Drug-Induced?

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Abstract
To the Editor: Agranulocytosis is one of the most commonly reported adverse reactions to drugs, second only to skin rashes. Idiosyncratic agranulocytosis may or may not be dose dependent; it is unpredictable and usually reversible upon discontinuation of the drug, but the risk of infection precludes further use of the offending agent. However, normal white-cell counts vary among persons and tend to be lower in certain racial and ethnic groups, such as blacks1 and people of Mediterranean origin.2 Moreover, various idiopathic forms of leukopenia, such as chronic idiopathic neutropenia, transient cyclic leukopenia, or "pseudoneutropenia" (i.e., neutrophils shifted to the marginated . . .

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