Involvement of lymphocyte function-associated antigen-1 (LFA-1) in HIV infection: inhibition by monoclonal antibody

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Abstract
Monoclonal antibodies (MAbs) against the α- and β-chain of lymphocyte-associated antigen-1 (LFA-1) were examined for inhibition of HIV-1 infection in vitro. Infection of the T cell line MT4 and the monocytic cell line U937 by isolates HTLVIIIB and SSI-002, respectively was inhibited in a concentration dependent manner by MAb against the β-chain but not against the α-chain. No cross-reactivity was found between MAb against LFA-1 and against the CD4 receptor (MAb Leu3a). MAbs against the β-chain and the CD4 receptor were found to act synergistically in inhibiting HIV infection. These data indicate that the β-chain of LFA-1 in addition to the CD4 receptor may be involved in HIV infection in vitro.