Aluminium Phosphate but Not Calcium Phosphate Stimulates the Specific IgE Response in Guinea Pigs to Tetanus Toxoid

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Abstract
The ability of aluminium phosphate and calcium phosphate to stimulate the synthesis of tetanus toxoid-specific anaphylactic and antitoxic antibodies was compared. The observed differences in the kinetics of Ig[immunoglobulin]G1a, IgG1b and antitoxins were quantitative titers after application of aluminium phosphate were higher. Booster immunization with Al but not calcium phosphate-adsorbed toxoid led to a prolonged synthesis of specific IgE. The regular application of Al compound-containing vaccines on the entire population could be 1 of the factors leading to the observed increase of allergic diseases.