Adenosine 3′,5′-Monophosphate: Inhibition of Complement-Mediated Cell Lysis
- 15 February 1974
- journal article
- book review
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4125) , 659-661
- https://doi.org/10.1126/science.183.4125.659
Abstract
An increase in adenosine 3',5'-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E1, by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.Keywords
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