Generality in effects of transmucosal fluid movement and glucose on drug absorption from the rat small intestine.

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Abstract
The generality in effects of transmucosal fluid movement and glucose on drug absorption from the rat small intestine was investigated using 23 drugs having different charges in the physiological pH of the intestine of the animal with the in situ recirculating perfusion method. All of the regression lines representing the relation between ratio of the transmucosal fluid movement on the vertical axis and intestinal absorption of respective drugs on the horizontal axis were not perpendicular to the horizontal axis but have some inclinations without exception. The evidence did support the concept that intestinal drug absorption was subtly affected by the transmucosal fluid movement and thus the generality in effect of the movement was apparently demonstrated. Concerning the glucose effect, 2 regression lines, one of NaCl and another of glucose in the perfusate, were obtained in all of the drugs, but these 2 regression lines overlapped in unionized drugs. In cationic drugs, the regression lines of glucose were always shifted significantly to the right side of those NaCl and in anionic drugs the regression lines of glucose were shifted to the left side without any exception. The evidence demonstrated that glucose increased the absorption of cationic drugs and decreased that of anionic drugs; these findings were supported by investigating blood level of respective drugs in the subjected animal. Thus the generality in the glucose effect was apparently demonstrated. The glucose effect was also recognized when 2 drugs coexisted simultaneously in the perfusate. The glucose effect in drug absorption might be one of the mechanisms of drug interactions observed in clinical medicine.